A FACILE SYNTHESIS OF (S) – (-) – PROPRANOLOL

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Abstract:

A one-pot synthesis of (S)-(-)-propranolol is reported. Zn(NO3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.

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Journal title

volume 14  issue 1

pages  -

publication date 2003-03-01

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